题目: “Cross-species and cross-life stage extrapolation of toxicity to fishes using experimental and computational models”
主讲人：Dr. Markus Brinkmann
Dr. Markus Brinkmann，加拿大萨斯喀彻温大学环境与可持续发展学院助理教授，萨斯喀彻温大学毒理学中心、环球水安全研究所成员，德国亚琛工业大学生物学博士学位，主要研究领域为：基于生理学的毒代动力学建模，鱼类对污染物吸收及影响的种间推断及环境因素对水生生物环境污染物生物利用度的影响。
Current regulations for the assessment of the toxicological risks of chemicals released into the environment around the globe rely on extensive live-animal testing using a few standard model species. In addition to the huge costs and ethical objections regarding animal testing, these approaches are often not adequately protective of organisms of concern, such as native species of fishes. In my research group, we use a number of experimental and computational models to bridge this gap. In this presentation, I will focus on two examples: (1) an in vitromodel to predict the sensitivity of early-life stages of European eels to dioxin-like chemicals, and (2) a computational model to extrapolate the bioaccumulation potential of chemicals across different fish species. Successful implementation of these approaches in chemical risk assessment will represent a great step towards more sustainable, efficient, and unbiased assessments of the safety of the large number of chemicals in use today and in the future.